iloperidone boosts amounts of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe. Iloperidone is a time-dependent CYP3A inhibitor and may lead to elevated plasma amounts of drugs predominantly removed by CYP3A4.Use of benzodiazepines, including diazepam, both used alone and together with other CNS depressants, ma